Effects of Input Parameters Report Writing - Medical Science Assignment Help

Assignment Task

Task

Introduction

Alzheimer's Disease.

Neurological illnesses affect around 1.5 billion individuals worldwide, increasing the figure. As a result of clinical trial failures, the number of participants enrolled in clinical trials increases. Alzheimer's disease is a neurological illness that affects the elderly and causes them to become debilitated (Rahman et al., 2019). Alzheimer's disease (AD) is a neurodegenerative disease in which the brain's cognitive abilities decline over time due to its neurodegenerative nature. 

Conditions characterized by cholinergic activity Senile dementia is one of the clinical manifestations of Alzheimer's disease. Despite this, Alzheimer's disease (AD) (Rahman et al., 2018) is afflicted by an unknown cause and unmet healthcare needs. Because of the complexity of multifactor Alzheimer's disease, developing a treatment for it is difficult. Effective antimolecules for Alzheimer's disease have not yet been able to reach therapeutic concentrations in the brain because of obstacles such as the blood-brain barrier (BBB), bioavailability, or pharmacokinetics (Khan et al., 2017). If the brain maintains a healthy state of homeostasis, it is necessary to protect the BBB from damage. Drugs such as Curcumin and other phenolic compounds, for example, have been changed to improve drug delivery to the brain in patients suffering from inflammatory disorders. Surface modification can direct curcumin nanoparticles toward specific targets or enhance their passage through the blood-brain barrier (BBB) when it comes to curcumin nanoparticles. Researchers produced curcumin-conjugated nanoliposomes to prevent the formation of amyloid plaques (CnLs). 

It is possible to deliver different carriers into the central nervous system without invasively exploiting transporter substrates overexpressed in the blood-brain barrier (BBB), connecting nanoparticles to specific receptors on the surface, and conveying via adsorption using an opposite electrical charge relationship, among other approaches (negative for the endothelial cell membrane and positive for the carrier). Because of the dangers involved, it has not been possible to open a narrow intersection in the past intentionally. The usage of peptides is another option to consider. Trans activating-transduction peptides (TAT) are a promising treatment option since they have been carefully crafted to maximize efficacy while minimizing side effects. The ability of curcumin nanoparticles to target the central nervous system is significantly altered by the addition of surface agents into the formulation (CNS). Curcumin is frequently coupled with another active chemical, such as puerarin or dexanabinol, to increase potency and effectiveness. Alzheimer's disease is discovered using a genetic test (AD.) Curcumin-coupled magnetic particles have been used to create abeta plaques, gold–iron oxide nanocomposite systems, and other applications. Additionally, P. Ghorbani (2018) discovered that some biodegradable polymeric NPs have become well-known for their usage in drug administration. Because of their potential to function as drug delivery vehicles, therapeutic molecules ejected from a damaged brain area can be protected and administered controlled, regulated, or site-specific. 

Compared to traditional NPs, nanoparticles have a higher surface-to-volume ratio and require a lower dose of DDS. In various reports, polymeric NPs (intranasal delivery of medicines, vaccinations, and proteins) are effective in the delivery of a wide range of pharmaceuticals (drugs, vaccines, and proteins) (Karthivashan et al., 2018). When it comes to the sector of nanotechnology, which is currently undergoing a boom, design and development breakthroughs are taking place. Chitosan (CS) is a chemical molecule used to target drugs to the brain. Biopolymers are currently being used to target drugs to the brain. The list of CS authors accepted illustrates the progression of AD Chitin, a naturally occurring cationic polysaccharide, which is deacetylated to generate polymer. Protonation occurs when CS is dissolved in acid, which increases the compound's solubility in water. CS is a chemical compound that is insoluble in water. 

CS's capacity to stick to the mucosal surface allows it to exert its effects longer than other agents (Sreekumar et al., 2018). CS has several advantages, including biocompatibility, low toxicity, and opening cellular tight junctions (Rassu et al., 2019). The administration of a brain medication through the nose has been accomplished using CS drug delivery. 

According to research, therapeutic quantities of intranasal medication can be achieved through the olfactory bulb and cerebrospinal fluid (CSF). Neuropeptides, for example, have been shown in pre-clinical and clinical trials to bypass the bloodstream and reach the CSF. Additionally, an IN (intravenous) way of giving medication is available that is non-invasive and painless.

Aim of the study:

1. To create Curcumin chitosan-caged Curcumin (CS-Curcumin) liposomes by thin-film hydration employing phospholipid and cholesterol as encapsulated lipid bilayers in varied ratios.

2. Research the size of curcumin-containing liposomes and ways to reduce their size.

3. Optimize the preparation procedure by measuring the entrapment efficiency in prepared formulations.

4. Use accelerated stability testing to investigate the stability of liposomal compositions.

5. Examine the effects of 5 input parameters on particle size distribution , rehydration duration, rehydration volume, sonication time, drug: lecithin ratio and temperature.

This Medical Science Assignment has been solved by our Medical Science Expert at Exam Question Bank. Our Assignment Writing Experts are efficient to provide a fresh solution to this question. We are serving more than 10000+ Students in Australia, UK & US by helping them to score HD in their academics. Our Experts are well trained to follow all marking rubrics & referencing Style. Be it a used or new solution, the quality of the work submitted by our assignment experts remains unhampered. You may continue to expect the same or even better quality with the used and new assignment solution files respectively. There’s one thing to be noticed that you could choose one between the two and acquire an HD either way. You could choose a new assignment solution file to get yourself an exclusive, plagiarism (with free Turn tin file), expert quality assignment or order an old solution file that was considered worthy of the highest distinction.

Assignment Task

Task

Introduction

Alzheimer's Disease.

Neurological illnesses affect around 1.5 billion individuals worldwide, increasing the figure. As a result of clinical trial failures, the number of participants enrolled in clinical trials increases. Alzheimer's disease is a neurological illness that affects the elderly and causes them to become debilitated (Rahman et al., 2019). Alzheimer's disease (AD) is a neurodegenerative disease in which the brain's cognitive abilities decline over time due to its neurodegenerative nature. 

Conditions characterized by cholinergic activity Senile dementia is one of the clinical manifestations of Alzheimer's disease. Despite this, Alzheimer's disease (AD) (Rahman et al., 2018) is afflicted by an unknown cause and unmet healthcare needs. Because of the complexity of multifactor Alzheimer's disease, developing a treatment for it is difficult. Effective antimolecules for Alzheimer's disease have not yet been able to reach therapeutic concentrations in the brain because of obstacles such as the blood-brain barrier (BBB), bioavailability, or pharmacokinetics (Khan et al., 2017). If the brain maintains a healthy state of homeostasis, it is necessary to protect the BBB from damage. Drugs such as Curcumin and other phenolic compounds, for example, have been changed to improve drug delivery to the brain in patients suffering from inflammatory disorders. Surface modification can direct curcumin nanoparticles toward specific targets or enhance their passage through the blood-brain barrier (BBB) when it comes to curcumin nanoparticles. Researchers produced curcumin-conjugated nanoliposomes to prevent the formation of amyloid plaques (CnLs). 

It is possible to deliver different carriers into the central nervous system without invasively exploiting transporter substrates overexpressed in the blood-brain barrier (BBB), connecting nanoparticles to specific receptors on the surface, and conveying via adsorption using an opposite electrical charge relationship, among other approaches (negative for the endothelial cell membrane and positive for the carrier). Because of the dangers involved, it has not been possible to open a narrow intersection in the past intentionally. The usage of peptides is another option to consider. Trans activating-transduction peptides (TAT) are a promising treatment option since they have been carefully crafted to maximize efficacy while minimizing side effects. The ability of curcumin nanoparticles to target the central nervous system is significantly altered by the addition of surface agents into the formulation (CNS). Curcumin is frequently coupled with another active chemical, such as puerarin or dexanabinol, to increase potency and effectiveness. Alzheimer's disease is discovered using a genetic test (AD.) Curcumin-coupled magnetic particles have been used to create abeta plaques, gold–iron oxide nanocomposite systems, and other applications. Additionally, P. Ghorbani (2018) discovered that some biodegradable polymeric NPs have become well-known for their usage in drug administration. Because of their potential to function as drug delivery vehicles, therapeutic molecules ejected from a damaged brain area can be protected and administered controlled, regulated, or site-specific. 

Compared to traditional NPs, nanoparticles have a higher surface-to-volume ratio and require a lower dose of DDS. In various reports, polymeric NPs (intranasal delivery of medicines, vaccinations, and proteins) are effective in the delivery of a wide range of pharmaceuticals (drugs, vaccines, and proteins) (Karthivashan et al., 2018). When it comes to the sector of nanotechnology, which is currently undergoing a boom, design and development breakthroughs are taking place. Chitosan (CS) is a chemical molecule used to target drugs to the brain. Biopolymers are currently being used to target drugs to the brain. The list of CS authors accepted illustrates the progression of AD Chitin, a naturally occurring cationic polysaccharide, which is deacetylated to generate polymer. Protonation occurs when CS is dissolved in acid, which increases the compound's solubility in water. CS is a chemical compound that is insoluble in water. 

CS's capacity to stick to the mucosal surface allows it to exert its effects longer than other agents (Sreekumar et al., 2018). CS has several advantages, including biocompatibility, low toxicity, and opening cellular tight junctions (Rassu et al., 2019). The administration of a brain medication through the nose has been accomplished using CS drug delivery. 

According to research, therapeutic quantities of intranasal medication can be achieved through the olfactory bulb and cerebrospinal fluid (CSF). Neuropeptides, for example, have been shown in pre-clinical and clinical trials to bypass the bloodstream and reach the CSF. Additionally, an IN (intravenous) way of giving medication is available that is non-invasive and painless.

Aim of the study:

1. To create Curcumin chitosan-caged Curcumin (CS-Curcumin) liposomes by thin-film hydration employing phospholipid and cholesterol as encapsulated lipid bilayers in varied ratios.

2. Research the size of curcumin-containing liposomes and ways to reduce their size.

3. Optimize the preparation procedure by measuring the entrapment efficiency in prepared formulations.

4. Use accelerated stability testing to investigate the stability of liposomal compositions.

5. Examine the effects of 5 input parameters on particle size distribution , rehydration duration, rehydration volume, sonication time, drug: lecithin ratio and temperature.

This Medical Science Assignment has been solved by our Medical Science Expert at Exam Question Bank. Our Assignment Writing Experts are efficient to provide a fresh solution to this question. We are serving more than 10000+ Students in Australia, UK & US by helping them to score HD in their academics. Our Experts are well trained to follow all marking rubrics & referencing Style. Be it a used or new solution, the quality of the work submitted by our assignment experts remains unhampered. You may continue to expect the same or even better quality with the used and new assignment solution files respectively. There’s one thing to be noticed that you could choose one between the two and acquire an HD either way. You could choose a new assignment solution file to get yourself an exclusive, plagiarism (with free Turn tin file), expert quality assignment or order an old solution file that was considered worthy of the highest distinction.