Points to remember:
Points to remember:
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Your assessment should be approximately 9,000 words in length.This is to include headings, contents, legends etc and the citations inthe text, but not the reference list.
Line spacing should be 1.5 with Font size 12 (Calibri) is recommended.
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Draft Submission:8Aug2024
Fianl sunmission 13Au2023
Title: fendiline as potential anticancer agents
Dessertation structure
This research aims to synthesize fendiline and evaluate the activity for possible anti-cancer agents using an MTT assay
Chapter 1:
Introduction
Introduction to cancer (definition, types,Symptoms(Lung,Pancreatic,breast cancer,Brain,Blood cancer,Colon Cancer etc), symptoms, prevalence, etc),over view of cancer
The eukaryotic cell cycle
Cancer treatment:Examples (surgery.,radiation,chemotherapy ,Nonotechnologyetc)
Chemotherapeutic drugs
Alkylating agents-cisplatin
Antimetabolites
Inhibitors of purine and pyrimidine biosynthesis
Anti-folates
Anti-microtubule agents
Topoisomerase inhibitors
Cytotoxic antibiotics
Chemotherapy resistance:How to overcome(ex stemcells,Advantages of non traditional drugs)
Drug repositioning (why,where used,how it is successful?)
Current issues of traditional drug discovery pathway
Thats why particularly we focus fendiline as novel anticancerous drugs for this study.
Fendiline and derivatives :(What is fendiline,why it is useful)
Fendiline synthesis -Explain mechanisam of action,observed anticancer properies,)
Different types of synthetic pathways of fendiline in general10
Rational of the study
Aim :
objectives : (syntesis,charactersation,check anticancer properties,name of compound)
Chapter 2
Materials and Methods
Chapter 3
Results:
NMR Spectra: For structural determination of unknown compounds
2,IR spectra:please label
3.MTT Assay: please label
(include IC 50 -Graph)
Cisplatin is used as standard.Both drug compound and cisplatin absorbance is taken under 540nm and 690nm
Chapter 4(40% of mark)
Discussion:
Chapter 5
Conclusion
Chapter 6
Future Studies
Note:Please label the below images
Results:Calculation of Percentage yield (%):
The percentage of the yield is determined by using the below formula;
Percent Yield= (Actual Yield/Theoretical Yield) 100%
Image 1: Round bottom flask contains crude product after drying
Weight of the empty round bottom flask=74.7103g
Weight of the round bottom flask with crude product=74.8973g
Therefore, the actual yield obtained =0.187g
Calculation of Rf Value:
Image 2:TLC plate under UV lampshowing distance travelled by the control and Drug product
Distance travelled by the drug compound =3.5cm
Distance travelled by solvent=4cm
Distance travelled by control(Amine)=1cm
NMR Spectra:
IR Spectra:
MTT ASSAy
Calculate IC 50 values using Graph prism:
