Materials and Methods

Materials and Methods

Patient Recruitment, sample selection and Data Collection

The Study samples were selected from pregnant participants from the Queensland Family Cohort (QFC) based at Mater Hospital. 24 patients within 24-28 weeks of gestation are recruited for this study. The recruited patients were categorized into three groups, and this included :

Control group (uncomplicated pregnant patients)

GDM patient group treated with diet

GDM patient group treated with medication (metformin/insulin)

To minimise potential confounding factors, the study participants were matched as closely as possible for maternal age, body mass index (BMI), gestation at delivery and baby weight. Based on the QFC criteria, the inclusion criteria included the following:

Pregnant patients who are permanent residents of Australia and reside in QLD (39).

Participants who are 24-28 weeks pregnant (uncomplicated pregnancies, GDM patients treated diet and those treated with insulin or metformin medication).

Eligible individuals including those from non-English speaking backgrounds (39).

The exclusion criteria included the following:

Participant and partner consent was not given(39).

Women with severe systemic disease.

Women with preeclampsia

The ethical approval for this sub-study of the Queensland Family Cohort (QFC) was obtained from the Mater Research Ethics (HREC/16/MHS/113) (). The participants were approached for study participation by qualified experienced research midwives via SMS, phone or face-to-face. Furthermore, social media and marketing campaigns were used to recruit participants. Participants who were interested in the study and met the eligibility criteria were provided with sufficient information about the study before obtaining written consent.

Research Electronic Data Capture (REDCap) has been used to collect and manage data collected from participants in QFC (Mater Hospital) (). Questionnaires that included questions about lifestyle and health status are completed by eligible participants. Surveys completed by participants included demographic details (age, employment, education,), clinical characteristics, medical history, medication, and drug use().

Plasma blood samples were collected at 24-28 weeks of pregnancy and stored at -80C until miRNA extraction was performed.

miRNeasy/ plasma kit for purification of total RNA including miRNA and quantification using the Nanodrop

The miRNA was extracted from 500 L of blood plasma using the miRNeasy Serum/Plasma Kit (Qiagen, Hilden, Germany) following the manufacturers instructions (). Briefly, the kit included a QIAzol lysis reagent which is added to the plasma sample. Afterwards, chloroform is added to the mixture to prepare for the separation step. Centrifugation is done to separate the lysate into a colourless aqueous phase, white interphase, and organic phase. The aqueous phase is collected and then ethanol is added (). The sample is then placed on the RNeasy MinElute spin column, wherein the total RNA can attach to the membrane with the phenol and other contaminants being washed away (). In the final step, 14 l RNase-free water is added to elute the RNA (). The purification of cell-free total RNA will include the miRNA, which is then used for miRNA profiling . Afterwards, the Nanodrop spectrophotometer is used to assess the quantity and quality of the miRNAs obtained. The Nanodrop does this by measuring the RNA concentration in UV light .

Table SEQ Table * ARABIC 1.Nanodrop Results

Sample No. Sample ID Group Extracted 260/280 260/230 ng/l

1 Ctrl 044a 10/03/2023 1.27 0.69 38.3

2 Ctrl 048a 10/03/2023 1.06 0.42 18.5

3 Ctrl 054a 9/03/2023 1.27 0.13 8.9

4 Ctrl 078a 9/03/2023 1.37 0.11 14.2

5 GDMD 010a 14/03/2023 1.34 0.04 12.5

6 GDMD 017a 14/03/2023 1.5 0.1 24.4

7 GDMD 047a 16/03/2023 1.53 0.16 30.2

8 GDMD 138a 16/03/2023 1.59 0.34 19.9

9 GDMM 074a 30/03/2023 1.32 0.41 44.5

10 GDMM 114a 30/03/2023 1.16 0.42 7.3

11 GDMM 116a 30/03/2023 1.54 0.11 29.8

12 GDMM 154a* 30/03/2023 1.74 0.04 12.4

13 Ctrl 112a 10/03/2023 1.29 0.78 8.9

14 Ctrl 131a 10/03/2023 1.37 0.66 13.2

15 Ctrl 141a 14/03/2023 1.47 0.17 21.6

16 Ctrl 178a 14/03/2023 1.55 0.09 18.9

17 GDMD 147a 16/03/2023 1.36 0.48 28.6

18 GDMD 162a 16/03/2023 1.54 0.27 28.7

19 GDMD 186a 16/03/2023 1.37 0.32 13.6

20 GDMD 193a 16/03/2023 1.45 0.16 13.5

21 GDMM 161a 30/03/2023 1.33 0.43 26.6

22 GDMM 199a 30/03/2023 1.5 0.41 20.7

23 GDMM 209a 30/03/2023 1.47 0.18 25

24 GDMM 016a 30/03/2023 1.51 0.1 17.5

Post-extraction enrichment

RNA samples (11 l) were diluted in 410 l of DNase/Rnase-free water (ZYMO Research, USA, Cat.No: W1001-4) and loaded into AMICON ULTRA 0.5ML 3Kda (MERG, Australia) columns and centrifuged at 14,000 g for 90 mins at room temperature. Columns were inverted and placed into new tubes and centrifuged at 8,000 g for 2 mins to elute approximately 25 l enriched miRNA.

NanoString Analysis for miRNA Profiling

The extracted miRNAs were measured using the NanoString nCounter system located at the Griffith University Central Facility for Genomics. The specific system used is the nCounter Human V3 miRNA Assay Panel which can rapidly and effectively profile 800 miRNAs in each sample (). The Human V3 miRNA Panel contains 799 probes that represent >95% of all human miRBase reads (). The assay provides direct, digital counts of each miRNA without the use of reverse transcription or amplification (). It is a form of targeted discovery and validation tool that allows the collection of expression data in a minimal amount of time with less hands-on manipulation (). Colour-coded probe pairs are used to establish direct molecular barcoding and digital detection of target molecules ().

The nCounter miRNA sample preparation method involves multiplexed ligation of the specific tags to their target miRNA and an enzymatic purification to remove unligated tags. The Tm-optimized bridging oligos that correspond to a portion of both the target miRNA and miRNA-specific tag as well as stepwise control of annealing and ligation temperatures are used to verify the sequence specificity of the ligation reaction (). The n-counter system has inbuilt positive and negative controls to improve performance ().

miRNA Sample Preparation Protocol

1 l of the miRNA Assay Controls was diluted in 499 l Dnase/Rnase-free water, mixed, and left on ice until use. 3 l of sample RNA was combined with 3.5 l of the Annealing Master Mix (13 l Annealing Buffer, 26 l nCounter miRNA Tag Reagent, and 6.5 l of the 1:500 diluted miRNA Assay Controls) in 0.2 ml 12-well strip tubes. The strip tubes were sealed with strip tube lids and placed onto a thermocycler running the Annealing Protocol (Table 2).

Table SEQ Table * ARABIC 2.Annealing Protocol

Protocol Temp Time

Annealing Protocol 94C 1 min

65C 2 min

45C 10 min

48C Hold

Total Time 13 minutes

Ligation Protocol 48C 3 min

47C 3 min

46C 3 min

45C 5 min

65C 10 min

4C Hold

Total Time 24 minutes Purification Protocol 37C 1 hour

70C 10 min

4C Hold

Total Time 1 hour 10 minutes

Following completion of the Annealing Protocol, 2.5 l of the ligation master mix (22.5 l PEG, 15 l Ligation Buffer) was added to each tube, mixed by flicking, centrifuged briefly, and returned to the thermocycler at 48C for 5 min. With the strip tubes remaining in place on the thermocycler, 1 l of Ligase was added to each tube, and the strip tubes capped. The thermocycler was closed, and the Ligation Protocol was immediately run (Table 2). Following completion of the Ligation Protocol, 1 l Ligation Clean-Up Enzyme was added to each tube, mixed by flicking, and briefly spun down. The tubes were returned to the thermocycler to run the Purification Protocol. Following completion of the Purification Protocol, 40 l of Dnase/Rnase-free water was added to each strip tube well and each sample transferred to sterile 1.5 mL microcentrifuge tubes for storage at -20C until use.

miRNA CodeSet Hybridization Setup Protocol

A thermocycler was pre-heated to 65C and 70C heated lid set to run infinite. Human V3 miRNA (241004) Reporter CodeSet (Lot. RC9901) and Capture ProbeSet (Lot. CP9789) reagents were removed from -80C storage and allowed to thaw on ice, protected from light. Samples were removed from -20C storage and allowed to thaw to room temperature on the bench. Samples were then denatured in a heat block at 85C for 5 mins and then transferred to ice to quick-cool.

In 0.2 mL 12-well strip tubes, 5 l of each sample was added to 20 l of hybridization master mix (130 l Hybridisation Buffer in the tube of Reporter CodeSet) per well, and 5 l Capture ProbeSet to each tube. Strip tubes were mixed by flicking, briefly spun down and placed in the thermocycler to incubate for 22 hours.

nCounter Sample Preparation

Nanostring nCounter cartridges and prep-plates were removed from cold-storage and allowed to thaw to room temperature for 15 minutes. A NanoString Max/Flex machine was programmed to run on high sensitivity. NanoString nCounter prep-plates were centrifuged at 2,000 g for 2 min at room temperature and loaded onto the Max/Flex Prep-Station. The nCounter cartridge was loaded into position and the 12-well strip tube with samples was removed from incubation and loaded onto the Prep-Station machine.

Following completion of the prep-station run, the cartridge was sealed to prevent evaporation of probes and transferred to an nCounter machine for enumeration.

nSolver analysis

The TECH NOTE nCounter miRNA Expression Analysis in Plasma and Serum Samples was used as a guide to normalise this data using a process that involves utilising the NormFinder algorithm in R, to find the most suitable genes within the data set to use as housekeepers for normalisation.

Raw data (RCC files) were imported into nSolver, and two experiments were generated (one for each run). The first step involved parsing out the most suitable candidate genes for processing using NormFinder. We used background subtraction of the mean of negative controls plus 1 standard deviation. We turned off all normalisation options at this stage and exported the normalised data to a csv file. There we excluded any endogenous or housekeeping genes with an mean expression less than 25 counts (RUN1) or 50 counts (RUN2).

We wrangled the data to fit the expected structure needed for NormFinder and ran the algorithm to return the top 5 genes to be used as housekeepers. Using this list, we returned to nSolver and manually included the 5 genes into the list of Housekeepers and discarded any preselected Housekeepers that had overly high coefficient of variation percentage (CV%).

Statistical analysis

Differential miRNA Expression Analysis

The raw data was normalized and analysed using the ROSALIND (https://rosalind.bio/), with a HyperScale architecture developed by ROSALIND, Inc. (San Diego, CA). Read Distribution violin plots, identity heatmaps, and sample MDS plots were generated as part of the QC step. The limma R library1 was used to calculate fold changes and p-values and perform optional covariate correction. Clustering of miRNA for the final heatmap of differentially expressed miRNA was done using the PAM (Partitioning Around Medoids) method using the fpc R library2. The top targeted gene predictions, validated genes, and related drugs and disease were analysed using the multiMiR R library3. miRNA secondary structures were calculated and visualized using the ViennaRNA software4.

Rosalind enabled Comparisons between the GDMD vs Control, GDMM vs Control and GDMD vs GDMM groups. The fold changes and p-values for comparisons were calculated using the t-test method (p 0.05). p-value adjustment was performed using the BenjaminiHochberg (p 0.01) method to estimate false discovery rates (FDR). For the purpose of this study, adjusted p-values were reported. MiRNAs with the fold change and p-adjusted value threshold of 1.5 and 0.05 respectively were considered significant. Fold change (1.5 for miRNAs upregulated and 1.5 for miRNAs downregulated), These comparisons provided an overview of the altered miRNA expression in the groups studied. The results were displayed in tables and visualised in violin plots and heat maps.

Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis using DIANA-mirPath v4.0

To supplement the analyses, the DIANA-mirPath v4.0 miRNA pathway analysis web server was used to perform the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway) analysis using gene targets predicted by target scan v8.0. The KEGG database links genomic information with functional information for systemic analysis. Fishers exact t-test was performed to explore over-represented pathways in KEGG analysis, and results with p0.05 were considered significant. KEGG pathway was performed using miRNAs that were identified differentially expressed in the groups studied from the Rosalind analysis. This step is helpful in determining which biological pathways are represented more than expected within the set of genes or proteins of interest. This helps in identifying the key biological processes or pathways that may be involved in the GDM groups studied.

Results

The data was analysed by ROSALIND (https://rosalind.bio/). Based on the nanostring analysis, a total of 800 miRNAs were included in the Rosalind analysis. The limma R library1was used to calculate fold changes and p-values. miRNAs with a fold change greater than 1.5 and adjusted p-value 0.05 were considered significant.

Table 3 describes the log 2-fold change and p-adjusted values for the differentially expressed in the comparison groups. Whilst Figures 1,2 and 3 describe miRNAs that are upregulated and downregulated. When comparing GDMD and control, there were eleven significant miRNAs with a log2 fold change greater than 0.58 and p-value 0.05(). The significantly upregulated miRNAs in this group included hsa-miR-151A-3P,hsa-miR-3144-5P,hsa-miR-496,hsa-miR-520D-3P,hsa-miR-520H,hsa-miR-548AR-5P,hsa-miR-548J-5P and hsa-miR-570-3P(). The significantly downregulated miRNAs in this group were hsa-miR-3614-5P,hsa-miR-548V, and hsa-miR-627-3P(0.

Twelve miRNAs were significantly different between GDMM and the control group().The significant upregulated miRNAs included hsa-miR-219B-3P,hsa-miR-4455,hsa-miR-548G-3P,hsa-miR-548N,hsa-miR-561-5P,hsa-miR-627-5P and hsa-miR-548A-5P ().Hsa-miR-198, hsa-miR-603, hsa-miR-378H , hsa-miR-615-3P and hsa-miR-378G were significantly downregulated in this group

Only five miRNAs were significantly different between the GDMD and GDMM group. All of the miRNAs in this group were significantly upregulated and included hsa-miR-126-3P,has-miR-1322,hsa-miR-2117,hsa-miR-320C, and hsa-miR-502-5p ().

Table SEQ Table * ARABIC 3. The differentially expressed miRNAs associated with each of the comparisons between the groups had a fold-change of 1.5 and p adjusted value 0.05.

Group Comparison Significant differentially expressed miRNAs Foldchange(log2) p-adjusted value

GDMD vs Control miR-3614-5P -0.65 5.98e-3

miR-548V -0.67 3.85e-3

miR-627-3P -0.59 0.01

miR-151A-3P 0.71 3.96e-3

miR-3144-5P 0.60 0.02

miR-496 1.70 3.14e-3

miR-520D-3P 0.68 0.02

miR-520H 0.59 0.01

miR-548AR-5P 0.66 6.27e-3

miR-548J-5P 0.61 0.01

miR-570-3P 0.68 6.38e-3

GDMM vs Control miR-198 -0.94 0.05

miR-378H -1.06 0.02

miR-219B-3P 0.94 0.05

miR-378G -1.02 0.03

miR-4455 1.04 0.02

miR-548G-3P 1.04 0.02

miR-548N 1.37 7.85e-4

miR-561-5P 0.99 0.03

miR-627-5P 1.22 5.21e-3

miR-548A-5P 1.17 5.24e-3

miR-615-3P -0.95 0.05

miR-603 1.18 5.24e-3

GDMM vs GDMD miR-126-3P 0.65 0.01

miR-1322 0.59 0.02

miR-2117 0.61 0.02

miR-320C 0.61 0.02

miR-502-5p 0.73 4.32e-3

Figure SEQ Figure * ARABIC 1.Volcano plot comparing GDMD vs control

Figure SEQ Figure * ARABIC 2.Volcano plot comparing GDMM vs control

Figure SEQ Figure * ARABIC 3. Volcano plot comparing GDMM vs GDMD

MiRNA target genes and KEGG pathway analysis

The differentially expressed miRNAs were selected for miRNA target prediction using the online tool DIANA-mirPath v4.0 with Targetscan v8.0., which is based on experimentally validated miRNAgene interactions. DIANA mirPAth v4.0 together with KEGG analysis was used to examine the significantly enriched (p<0.05) signalling pathways of the miRNA target genes and found that the differentially expressed miRNAs in all three groups were involved in insulin/glucose regulation. The most common types of enriched pathways, excluding cancers included metabolic pathways, Wnt signalling pathways, TGF-beta signalling pathways, and insulin signalling pathways. were related to cellular processes, signal transduction, the endocrine system, and

Table SEQ Table * ARABIC 4.The enriched KEGG pathways of miRNAs that were differentially expressed in the GDMD vs Control group from DIANA-mirPath v4.0.

Pathways Target Genes miRNA Names P-value

Pathways in cancer 437 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 3.1052E-20

Proteoglycans in cancer 184 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.3464E-13

Metabolic pathways 1115 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.5205E-11

ErbB signaling pathway 79 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 8.0222E-11

Axon guidance 153 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 2.1101E-10

Hippo signaling pathway 137 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 2.2417E-10

Focal adhesion 172 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 3.0369E-10

Calcium signaling pathway 195 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 4.2578E-10

Rap1 signaling pathway 172 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 6.1898E-10

EGFR tyrosine kinase inhibitor resistance 74 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 2.6158E-09

Ras signaling pathway 188 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 9.4644E-09

PI3K-Akt signaling pathway 277 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.6748E-08

Regulation of actin cytoskeleton 175 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 2.5361E-08

Colorectal cancer 77 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 3.3945E-08

FoxO signaling pathway 114 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 6.0789E-08

Pancreatic cancer 69 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 6.5993E-08

Wnt signaling pathway 138 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 7.6591E-08

Chronic myeloid leukemia 69 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 2.1006E-07

Signaling pathways regulating pluripotency of stem cells 125 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.9538E-07

MAPK signaling pathway 244 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 2.1696E-07

HIF-1 signaling pathway 93 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 3.2688E-07

Hepatocellular carcinoma 139 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 4.0056E-07

Autophagy - animal 117 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 4.7589E-07

Glioma 68 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 8.7765E-07

p53 signaling pathway 65 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 8.9957E-07

Prostate cancer 84 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.067E-06

Phosphatidylinositol signaling system 84 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.067E-06

Breast cancer 128 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.1574E-06

TGF-beta signaling pathway 85 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.7823E-06

Oxytocin signaling pathway 126 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.9548E-06

Neurotrophin signaling pathway 99 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 4.9702E-06

Cell cycle 102 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 8.0771E-06

Ubiquitin mediated proteolysis 111 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 8.7785E-06

Phospholipase D signaling pathway 122 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 9.6239E-06

Small cell lung cancer 81 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.2973E-05

cAMP signaling pathway 168 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.3478E-05

Tight junction 138 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.4212E-05

Gastric cancer 124 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.7468E-05

Renal cell carcinoma 59 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.9358E-05

JAK-STAT signaling pathway 128 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 1.9174E-05

Spinocerebellar ataxia 112 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 2.1586E-05

Parathyroid hormone synthesis, secretion and action 93 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 2.573E-05

Pathogenic Escherichia coli infection 164 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 3.0852E-05

Endometrial cancer 52 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 3.1868E-05

cGMP-PKG signaling pathway 132 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 3.4017E-05

Adherens junction 65 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 3.6041E-05

Hepatitis B 133 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 4.3831E-05

Insulin signaling pathway 116 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 6.8258E-05

Fc gamma R-mediated phagocytosis 80 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 6.811E-05

N-Glycan biosynthesis 44 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 7.1656E-05

Bacterial invasion of epithelial cells 65 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 7.7836E-05

Platelet activation 104 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 8.799E-05

Growth hormone synthesis, secretion and action 99 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00010122

Inositol phosphate metabolism 63 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00014058

Apelin signaling pathway 106 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00015275

Non-small cell lung cancer 65 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00015969

Central carbon metabolism in cancer 60 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00016446

Melanogenesis 83 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00019145

Hepatitis C 128 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00019971

Hedgehog signaling pathway 49 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00021296

Prolactin signaling pathway 59 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00022096

Choline metabolism in cancer 82 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00024629

Melanoma 61 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00025107

Terpenoid backbone biosynthesis 21 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00028218

Renin secretion 58 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00029598

Thyroid hormone signaling pathway 103 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00030062

Glucagon signaling pathway 87 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00036875

Inflammatory mediator regulation of TRP channels 78 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00038203

Shigellosis 190 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00038774

Leukocyte transendothelial migration 91 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00040057

Long-term potentiation 57 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00039528

Long-term depression 52 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00040705

Endocytosis 218 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00042698

AGE-RAGE signaling pathway in diabetic complications 87 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00061205

Dopaminergic synapse 106 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00061347

Basal cell carcinoma 53 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00062338

Transcriptional misregulation in cancer 148 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00065591

Insulin resistance 93 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00067092

AMPK signaling pathway 97 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00070385

Acute myeloid leukemia 55 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00069838

Platinum drug resistance 59 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00084546

Salmonella infection 194 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00092916

Yersinia infection 108 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00094648

mTOR signaling pathway 128 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00097481

Circadian entrainment 76 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00105649

Cushing syndrome 127 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00117104

Amino sugar and nucleotide sugar metabolism 41 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.0011812

Morphine addiction 76 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00173139

Protein processing in endoplasmic reticulum 138 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00188298

Mucin type O-glycan biosynthesis 29 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.0019482

Measles 116 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00205155

T cell receptor signaling pathway 85 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00238016

Regulation of lipolysis in adipocytes 48 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00252555

Amphetamine addiction 57 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00255381

Autophagy - other 28 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00275561

Various types of N-glycan biosynthesis 33 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00297137

Glutamatergic synapse 86 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00295354

Glycosaminoglycan biosynthesis - heparan sulfate / heparin 22 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00315617

Bladder cancer 35 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00347117

PPAR signaling pathway 62 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00369503

Lysine degradation 53 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00398358

GnRH signaling pathway 72 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00416163

Other types of O-glycan biosynthesis 39 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.0044053

Nicotine addiction 34 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00469686

Vascular smooth muscle contraction 99 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00522223

Longevity regulating pathway 77 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00529096

Circadian rhythm 26 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00543683

Purine metabolism 98 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00623665

Ferroptosis 33 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00632547

Arrhythmogenic right ventricular cardiomyopathy 59 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00728429

Epithelial cell signaling in Helicobacter pylori infection 59 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00728429

Pyrimidine metabolism 44 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00721988

Mitophagy - animal 57 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00712313

Sphingolipid signaling pathway 95 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00750182

Hippo signaling pathway - multiple species 25 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00757954

Fluid shear stress and atherosclerosis 105 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.00973823

Selenocompound metabolism 16 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01021852

Glycosphingolipid biosynthesis - lacto and neolacto series 24 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01050947

Cholinergic synapse 87 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01096579

Gastric acid secretion 59 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01136959

Synaptic vesicle cycle 65 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01157675

Apoptosis - multiple species 26 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01218323

VEGF signaling pathway 46 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01274083

Biosynthesis of cofactors 120 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01310077

Endocrine resistance 84 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01319447

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate18 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01383509

Chemokine signaling pathway 147 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01417742

Adrenergic signaling in cardiomyocytes 112 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01420707

Butanoate metabolism 23 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01448791

Non-homologous end-joining 12 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01503759

Alanine, aspartate and glutamate metabolism 30 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01498579

Vibrio cholerae infection 45 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01604238

Tryptophan metabolism 34 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01710821

Vasopressin-regulated water reabsorption 36 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-496,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01794523

C-type lectin receptor signaling pathway 82 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.01855359

Aldosterone-regulated sodium reabsorption 29 hsa-miR-151a-3p,hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520d-3p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.0197587

Pentose and glucuronate interconversions 29 hsa-miR-3144-5p,hsa-miR-3614-5p,hsa-miR-520h,hsa-miR-548aa,hsa-miR-548ar-5p,hsa-miR-548j-5p,hsa-miR-548t-3p,hsa-miR-548v,hsa-miR-570-3p,hsa-miR-627-3p 0.0197587

Figure SEQ Figure * ARABIC 4.Top 35 KEGG enriched pathways(GDMD vs Control)

Table SEQ Table * ARABIC 5.The enriched KEGG pathways of miRNAs that were differentially expressed in the GDMM vs Control group from DIANA-mirPath v4.0.

pathways Target Genes (n) miRNA Names P-value

Pathways in cancer 458 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 1.7511E-23

Axon guidance 166 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 1.6473E-15

Metabolic pathways 1173 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 4.4683E-14

Hippo signaling pathway 145 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 6.4207E-13

Regulation of actin cytoskeleton 190 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 1.4523E-12

Rap1 signaling pathway 182 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 2.6218E-12

Proteoglycans in cancer 186 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 4.6975E-12

Signaling pathways regulating pluripotency of stem cells 137 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 9.1184E-12

Ubiquitin mediated proteolysis 125 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 5.2407E-11

Colorectal cancer 82 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 1.2201E-10

PI3K-Akt signaling pathway 293 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 1.4752E-10

ErbB signaling pathway 80 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 2.6295E-10

FoxO signaling pathway 121 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 5.5954E-10

Ras signaling pathway 196 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 1.4182E-09

MAPK signaling pathway 259 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 1.9571E-09

Autophagy - animal 125 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 3.0468E-09

Hepatocellular carcinoma 148 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 3.7804E-09

Wnt signaling pathway 145 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 3.9032E-09

Calcium signaling pathway 198 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 6.2022E-09

Gastric cancer 135 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 2.8568E-08

Pancreatic cancer 71 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 3.3173E-08

EGFR tyrosine kinase inhibitor resistance 74 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 4.2734E-08

HIF-1 signaling pathway 97 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 5.3038E-08

Phospholipase D signaling pathway 131 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 8.5435E-08

Chronic myeloid leukemia 71 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 1.2268E-07

Spinocerebellar ataxia 121 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 1.2865E-07

Cell cycle 109 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 1.4311E-07

Yersinia infection 122 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 2.1334E-07

Prostate cancer 87 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 4.4724E-07

Basal cell carcinoma 60 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 4.5444E-07

Breast cancer 133 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 4.4596E-07

Fc gamma R-mediated phagocytosis 87 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 4.4724E-07

Focal adhesion 169 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 5.1053E-07

Renal cell carcinoma 63 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 5.748E-07

Pathogenic Escherichia coli infection 175 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 7.2387E-07

TGF-beta signaling pathway 88 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 8.4265E-07

Thyroid hormone signaling pathway 113 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 1.1337E-06

Small cell lung cancer 85 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 2.0607E-06

p53 signaling pathway 66 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 2.1642E-06

Endometrial cancer 55 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 2.7051E-06

Prolactin signaling pathway 64 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 4.1669E-06

Neurotrophin signaling pathway 102 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 4.8333E-06

cAMP signaling pathway 175 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 5.8682E-06

Adherens junction 68 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 8.8201E-06

Tight junction 143 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 1.037E-05

Aldosterone-regulated sodium reabsorption 35 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 1.3987E-05

AMPK signaling pathway 105 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 1.7634E-05

T cell receptor signaling pathway 94 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 1.91E-05

AGE-RAGE signaling pathway in diabetic complications 94 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 1.91E-05

Sphingolipid signaling pathway 107 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 2.0534E-05

cGMP-PKG signaling pathway 137 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 2.2311E-05

Choline metabolism in cancer 87 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 2.8629E-05

Glioma 67 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 2.9697E-05

Other types of O-glycan biosynthesis 44 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 3.6882E-05

Phosphatidylinositol signaling system 83 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 3.9886E-05

Central carbon metabolism in cancer 63 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 4.0148E-05

Oxytocin signaling pathway 126 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 4.8612E-05

JAK-STAT signaling pathway 131 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 4.7599E-05

Apelin signaling pathway 111 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 4.9093E-05

Shigellosis 201 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 4.913E-05

Melanogenesis 87 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 5.7423E-05

Hepatitis B 137 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 6.1976E-05

mTOR signaling pathway 137 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 6.1976E-05

Melanoma 64 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 7.1057E-05

Relaxin signaling pathway 109 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 7.7202E-05

N-Glycan biosynthesis 45 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 8.3858E-05

Arrhythmogenic right ventricular cardiomyopathy 66 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 9.1132E-05

Platinum drug resistance 63 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 9.4618E-05

Adrenergic signaling in cardiomyocytes 125 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00010061

Non-small cell lung cancer 67 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00015003

Cushing syndrome 135 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00014901

Glutamatergic synapse 93 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 0.00016701

Acute myeloid leukemia 58 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00017306

Leukocyte transendothelial migration 95 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.0001885

Bacterial invasion of epithelial cells 66 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00019638

Long-term depression 54 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00023769

PD-L1 expression and PD-1 checkpoint pathway in cancer 81 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00025242

Growth hormone synthesis, secretion and action 101 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00026071

Salmonella infection 204 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00026915

Autophagy - other 30 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00042714

Biosynthesis of cofactors 131 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00049554

Dopaminergic synapse 110 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00049356

mRNA surveillance pathway 85 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00058015

Inflammatory mediator regulation of TRP channels 80 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00058046

Apoptosis - multiple species 29 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00061284

Long-term potentiation 58 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00079069

Purine metabolism 105 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00083132

C-type lectin receptor signaling pathway 90 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00095979

Fluid shear stress and atherosclerosis 113 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 0.00107022

Bladder cancer 37 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00110577

Cholinergic synapse 94 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00112829

Gastric acid secretion 64 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 0.00125859

Morphine addiction 79 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00126124

Glycosaminoglycan biosynthesis - heparan sulfate / heparin 23 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00147255

Nicotine addiction 36 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00150621

VEGF signaling pathway 50 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00156792

Circadian entrainment 78 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00156501

Insulin signaling pathway 115 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00170871

Glycosphingolipid biosynthesis - lacto and neolacto series 26 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00177881

Glycosaminoglycan biosynthesis - keratan sulfate14 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00185343

Protein processing in endoplasmic reticulum 143 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.0020044

Mannose type O-glycan biosynthesis 22 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00213823

Butanoate metabolism 25 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.0025212

Hedgehog signaling pathway 48 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00264054

Various types of N-glycan biosynthesis 34 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.0027658

Platelet activation 102 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 0.00343148

Amoebiasis 86 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00342594

Transcriptional misregulation in cancer 150 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00358923

Pyrimidine metabolism 46 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00438761

Inositol phosphate metabolism 61 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.0044451

Parathyroid hormone synthesis, secretion and action 89 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 0.00461736

Hippo signaling pathway - multiple species 26 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.0052106

Mucin type O-glycan biosynthesis 29 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00518071

Endocytosis 220 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 0.00535811

Fanconi anemia pathway 45 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00562584

GnRH signaling pathway 74 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00577616

Chemokine signaling pathway 155 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00588875

Ferroptosis 34 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00626833

Pantothenate and CoA biosynthesis 19 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00641791

Chagas disease 87 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00661828

Lysine degradation 54 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00709299

Vascular smooth muscle contraction 102 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 0.00730174

Hypertrophic cardiomyopathy 75 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.0074222

Epithelial cell signaling in Helicobacter pylori infection 61 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00742708

Cholesterol metabolism 41 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00801951

Longevity regulating pathway 79 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00823305

Progesterone-mediated oocyte maturation 78 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00985641

Biosynthesis of unsaturated fatty acids 24 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.00979791

Thyroid cancer 35 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.0098622

Endocrine and other factor-regulated calcium reabsorption 45 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01026919

Amino sugar and nucleotide sugar metabolism 40 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01025769

Amphetamine addiction 57 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01040651

Serotonergic synapse 93 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01081119

Hepatitis C 125 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01122039

Glycosphingolipid biosynthesis - globo and isoglobo series 14 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01125287

Cysteine and methionine metabolism 42 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01159304

Carbon metabolism 90 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01232931

Gap junction 74 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01345489

Mitophagy - animal 58 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01363814

Oocyte meiosis 98 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01374636

Peroxisome 67 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01406802

Alanine, aspartate and glutamate metabolism 31 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01415314

Arginine and proline metabolism 41 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01463483

Insulin resistance 91 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01488446

Renin secretion 55 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01560508

beta-Alanine metabolism 25 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01691383

Biosynthesis of amino acids 59 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01753813

Dilated cardiomyopathy 79 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01778139

Folate biosynthesis 22 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01807504

Nicotinate and nicotinamide metabolism 30 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01839544

Selenocompound metabolism 16 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01857929

Regulation of lipolysis in adipocytes 47 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01908806

GABAergic synapse 74 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-378h,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603 0.01968541

SNARE interactions in vesicular transport 27 hsa-miR-198,hsa-miR-219b-3p,hsa-miR-378g,hsa-miR-4455,hsa-miR-518e-5p,hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-519c-5p,hsa-miR-522-5p,hsa-miR-523-5p,hsa-miR-548g-3p,hsa-miR-548h-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-561-5p,hsa-miR-603,hsa-miR-615-3p 0.0204153

Figure SEQ Figure * ARABIC 5.Top 35 enriched KEGG pathways (GDMM vs Control)

expressed in the GDMD vs Control group from DIANA-mirPath v4.0.

Table SEQ Table * ARABIC 6.The enriched KEGG pathways of miRNAs that were differentially expressed in the GDMM vs GDMD group from DIANA-mirPath v4.0.

Pathways Target Genes (n) miRNA Names P-value

Pathways in cancer 275 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 2.6432E-11

Axon guidance 108 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 8.1565E-10

Hippo signaling pathway 94 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 2.4804E-08

Renal cell carcinoma 48 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 3.5505E-08

Prostate cancer 63 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 7.3502E-08

Rap1 signaling pathway 115 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 9.8538E-08

ErbB signaling pathway 55 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 1.4674E-07

Ras signaling pathway 126 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 1.9241E-07

Phospholipase D signaling pathway 88 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 4.0188E-07

Calcium signaling pathway 126 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 8.2743E-07

PI3K-Akt signaling pathway 179 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 1.1231E-06

Focal adhesion 111 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 1.2587E-06

Signaling pathways regulating pluripotency of stem cells 85 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 2.1571E-06

Autophagy - animal 80 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 3.1882E-06

Regulation of actin cytoskeleton 114 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 4.0751E-06

Morphine addiction 59 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 4.2865E-06

Proteoglycans in cancer 112 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 4.846E-06

Oxytocin signaling pathway 86 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 5.4881E-06

Apelin signaling pathway 76 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 8.8089E-06

TGF-beta signaling pathway 59 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 1.0042E-05

Ubiquitin mediated proteolysis 76 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 1.7301E-05

Glioma 47 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 2.0567E-05

FoxO signaling pathway 74 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 2.8275E-05

EGFR tyrosine kinase inhibitor resistance 48 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 3.0632E-05

Neurotrophin signaling pathway 67 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 3.5957E-05

Hepatocellular carcinoma 90 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 4.2871E-05

Transcriptional misregulation in cancer 102 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 5.542E-05

Glycosaminoglycan biosynthesis - heparan sulfate / heparin 19 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 5.8783E-05

Colorectal cancer 50 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 6.2675E-05

MAPK signaling pathway 153 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 6.4505E-05

Spinocerebellar ataxia 75 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 8.8991E-05

Melanoma 44 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 9.3377E-05

Thyroid hormone signaling pathway 71 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00012549

Chronic myeloid leukemia 45 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00013266

Insulin signaling pathway 77 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.0002277

Melanogenesis 57 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00022193

Tight junction 89 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00027847

Growth hormone synthesis, secretion and action 66 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00034439

AMPK signaling pathway 66 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00045485

Breast cancer 80 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.0004804

Gastric cancer 79 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00066461

cGMP-PKG signaling pathway 84 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00085104

Glutamatergic synapse 59 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00110331

AGE-RAGE signaling pathway in diabetic complications 58 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00120504

Cholinergic synapse 61 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00120461

Central carbon metabolism in cancer 40 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00127393

Choline metabolism in cancer 54 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00130378

Endometrial cancer 34 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00143528

VEGF signaling pathway 34 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00143528

Hepatitis C 82 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00155089

HIF-1 signaling pathway 56 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00187445

Mucin type O-glycan biosynthesis 21 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00213774

cAMP signaling pathway 103 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.0021992

Pancreatic cancer 41 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00226129

Phosphatidylinositol signaling system 51 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00223937

Wnt signaling pathway 81 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00253672

Non-small cell lung cancer 42 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00281621

Cushing syndrome 82 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.0028378

Small cell lung cancer 50 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00319625

Circadian entrainment 50 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00319625

Shigellosis 119 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00322033

Sphingolipid signaling pathway 64 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00309459

mTOR signaling pathway 82 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00343775

Dopaminergic synapse 68 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00338446

Autophagy - other 20 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00372798

T cell receptor signaling pathway 56 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00394922

Parathyroid hormone synthesis, secretion and action 57 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.0045616

Nicotine addiction 24 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00454285

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate14 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00443992

N-Glycan biosynthesis 28 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00490123

GABAergic synapse 49 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.0057945

Arrhythmogenic right ventricular cardiomyopathy 40 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00599607

Longevity regulating pathway 51 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00615665

Bladder cancer 24 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00679114

Regulation of lipolysis in adipocytes 32 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00683853

p53 signaling pathway 38 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00718644

Yersinia infection 68 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00757698

Gap junction 48 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00804681

Hepatitis B 80 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00830328

Selenocompound metabolism 12 hsa-miR-1322,hsa-miR-2117,hsa-miR-502-5p 0.00843338

Long-term potentiation 36 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00862001

Relaxin signaling pathway 64 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00876513

GnRH signaling pathway 47 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00880024

Platelet activation 63 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.00953871

Adrenergic signaling in cardiomyocytes 73 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.01036018

GnRH secretion 37 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.01033413

Various types of N-glycan biosynthesis 22 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.01171807

Endocytosis 132 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.01270586

PD-L1 expression and PD-1 checkpoint pathway in cancer 48 hsa-miR-126-3p,hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.01263183

Inflammatory mediator regulation of TRP channels 48 hsa-miR-1322,hsa-miR-2117,hsa-miR-320c,hsa-miR-502-5p 0.01263183

Figure SEQ Figure * ARABIC 6.Top 35 KEGG enriched pathways(GDMM vs GDMD)