Research question for Controlled Randomized trial

Research question for Controlled Randomized trial

In the elderly patients diagnosed with vascular dementia (P), does non-pharmacological intervention (I) compared to antipsychotic medication (C) reduce behavioral symptoms and improve cognitive functions? (O) ?

Conduct a search using one relevant database (e.g. Medline, CINAHL, Scopus) find 4 to 6 article related to research question randomised controlled trial

Describe how and why you will appraise the methodological quality of papers identified from your database search to determine their appropriateness for inclusion in your synthesis in assessment 3.

Provide a summary table (template below) that reports your appraisal of the methodological quality of (a minimum of 4 and maximum of 8) papers identified from your database search in assessment 1 (this will determine their inclusion for synthesis in assessment 3). A minimum quality threshold criterion/cut off must be provided with a justification of why you would or would not include each paper in your final synthesis.

Report your search results with a description of why papers were excluded.

Provide a flow diagram that accurately reflects your search results and how you arrived with the final number of papers to be included in your synthesis in assessment 3 (Use the template provided).

Your submission must include the following headings/figures/tables:

Appraisal of methodological quality

Table 1: Results of appraisal of methodological qualityAssessment 2 template.docxDownload Assessment 2 template.docx

Search results

Figure 1: Flow diagramAssessment 2 Figure 1 Flow diagram template.pptxDownload Assessment 2 Figure 1 Flow diagram template.pptx

References

Assessment 2 example.pdfDownload Assessment 2 example.pdfPlease note:this example is a previous student submission. The assessment has since been modified so this example does not exactly match the current assessment requirements. It is an example only. You may not reproduce any part of this example as this will be match in Turnitin and will be regarded as plagiarism.

433753899597920115177165Section A: Is the basic study design valid for a randomised controlled trial?

00Section A: Is the basic study design valid for a randomised controlled trial?

Did the study address a clearly focused research question?

CONSIDER:

Was the study designed to assess the outcomes of an intervention?

Is the research question focused in terms of:

Population studied

Intervention given

Comparator chosen

Outcomes measured? Was the assignment of participants to interventions randomised? CONSIDER:

How was randomisation carried out? Was the method appropriate?

Was randomisation sufficient to eliminate systematic bias?

Was the allocation sequence concealed from investigators and participants? Were all participants who entered the study accounted for at its conclusion?

CONSIDER:

Were losses to follow-up and exclusions after randomisation accounted for?

Were participants analysed in the study groups to which they were randomised (intention-to-treat analysis)?

Was the study stopped early? If so, what was the reason? 886460102870Section B: Was the study methodologically sound?

00Section B: Was the study methodologically sound?

5375031367909

4.

Were the participants blind to intervention they were given?

Were the investigators blind to the intervention they were giving to participants?

Were the people assessing/analysing outcome/s blinded? Were the study groups similar at the start of the randomised controlled trial?

CONSIDER:

Were the baseline characteristics of each study group (e.g. age, sex, socio-economic group) clearly set out?

Were there any differences between the

study groups that could affect the outcome/s? Apart from the experimental intervention, did each study group receive the same level of care (that is, were they treated equally)?

CONSIDER:

Was there a clearly defined study protocol?

If any additional interventions were given (e.g. tests or treatments), were they similar between the study groups?

Were the follow-up intervals the same for each study group? 2025845158750

920750163195Section C: What are the results?

00Section C: What are the results?

Were the effects of intervention reported comprehensively?

CONSIDER:

Was a power calculation undertaken?

What outcomes were measured, and were they clearly specified?

How were the results expressed? For binary outcomes, were relative and absolute effects reported?

Were the results reported for each outcome in each study group at each follow-up interval?

Was there any missing or incomplete data?

Was there differential drop-out between the study groups that could affect the results?

Were potential sources of bias identified?

Which statistical tests were used?

Were p values reported? Was the precision of the estimate of the intervention or treatment effect reported?

CONSIDER:

Were confidence intervals (CIs) reported? Do the benefits of the experimental intervention outweigh the harms and costs?

CONSIDER:

What was the size of the intervention or treatment effect?

Were harms or unintended effects

reported for each study group?

Was a cost-effectiveness analysis undertaken? (Cost-effectiveness analysis allows a comparison to be made between different interventions used in the care of the same condition or problem.) Section D: Will the results help locally?

Section D: Will the results help locally?

Can the results be applied to your local population/in your context?

CONSIDER:

Are the study participants similar to the people in your care?

Would any differences between your population and the study participants alter the outcomes reported in the study?

Are the outcomes important to your population?

Are there any outcomes you would have wanted information on that have not been studied or reported?

Are there any limitations of the study that would affect your decision? Would the experimental intervention provide greater value to the people in your care than any of the existing interventions?

CONSIDER:

What resources are needed to introduce this intervention taking into account time, finances, and skills development or training needs?

Are you able to disinvest resources in one or more existing interventions in order to be able to re-invest in the new intervention? 899160132080APPRAISAL SUMMARY: Record key points from your critical appraisal in this box. What is your conclusion about the paper? Would you use it to change your practice or to recommend changes to care/interventions used by your organisation? Could you judiciously implement this intervention without delay?

00APPRAISAL SUMMARY: Record key points from your critical appraisal in this box. What is your conclusion about the paper? Would you use it to change your practice or to recommend changes to care/interventions used by your organisation? Could you judiciously implement this intervention without delay?