3d Structure of Tramadol & Absolute Configuration Science Assignment Help

Assignment Task

TASK 
Tramadol is an opioid analgesic, commonly used to treat chronic pain. It is administered as a racemic mixture whereby each isomer targets different pain receptor

Questions:
1. a. Re-draw the 3D structure of tramadol (using dashed- and wedged-line about each chiral center) and determine the absolute configuration of each chiral center by giving label (R/S).

b. Draw the 3D structures of all other tramadol isomers and determine the absolute configuration (R/S) for each chiral center.

c. Identify the tramadol isomers in (b) as enantiomer or diastereomer or meso compound.
d. Which tramadol isomers are in the racemic mixture and why it is given as racemic mixture?
2. Tramadol molecule contains a ring that could adopt different chair conformers. Based on above picture, draw both conformers and assess steric strain in each. Which conformer is the more stable one? Explain your answer (use Newman projection in your explanation)
 

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