526669071755Identification of studies via other methods
526669071755Identification of studies via other methods
00Identification of studies via other methods
56692874245Identification of studies via databases and registers
00Identification of studies via databases and registers
525589578740Records identified from:
Citation searching (n = 8)
00Records identified from:
Citation searching (n = 8)
303946677064Records removed before screening:
Duplicate records removed (n = 428)
Non-English language paper
(n = 31)
00Records removed before screening:
Duplicate records removed (n = 428)
Non-English language paper
(n = 31)
55961377064Records identified from*:
PubMed (n=2383)
Ovid/Medline & Embase (n=629)
Cochrane Trials (n=861)
00Records identified from*:
PubMed (n=2383)
Ovid/Medline & Embase (n=629)
Cochrane Trials (n=861)
-403543222567Identification
00Identification
24542509550
6189880169369001400175128905
304948078338Records excluded (title and abstract irrelevant to the topic
(n =3402)
00Records excluded (title and abstract irrelevant to the topic
(n =3402)
245364032829555943574930Records screened
(n =3414)
00Records screened
(n =3414)
135504464341
-1160940140495Screening
00Screening
30583576856Reports excluded:
Results from the trial not posted
(n = 2)
Antipyretic not used in the intervention (n =1)
Not an RCT (n =2)
Different primary outcome ( n=2)
Different independent variable (n=2)
00Reports excluded:
Results from the trial not posted
(n = 2)
Antipyretic not used in the intervention (n =1)
Not an RCT (n =2)
Different primary outcome ( n=2)
Different independent variable (n=2)
526457321590Reports assessed for eligibility
(n = 8)
00Reports assessed for eligibility
(n = 8)
775567829845Reports excluded:
Abstract irrelevant to topic
(n = 4 )Different primary outcome measured (n =1 )Animal Study (n = 2)
00Reports excluded:
Abstract irrelevant to topic
(n = 4 )Different primary outcome measured (n =1 )Animal Study (n = 2)
247650029464056197513335Reports assessed for eligibility
(n =12)
00Reports assessed for eligibility
(n =12)
7174865128270
24244303556000140086129667
540385110795Studies included in review
(n =4)
Reports of included studies
(n =2)
00Studies included in review
(n =4)
Reports of included studies
(n =2)
-133509170656Included
00Included
*Will use grey literature ( SIGLE) and Scopus, ProQuest to ensure a comprehensive literature search
Guide to preparing your poster
Use powerpoint as a template for your poster
This about the clarity of images and text look at posters around the University to get some ideas
Consider over-writing the posters that are available as examples in canvas
Set up your page as an A1 paper size or use custom size with a width of 59.4cm and a height of 84.1cm
The smallest font size that will be readable will be 12
Once you have prepared your poster please save this as a *jpeg file with the file name being your name in the format Surname_Firstname.jpeg; for example: Batchelor_Hannah.jpeg
Upload this to canvas
Author Design, Setting, Subjects, Age Antipyretic intervention Vaccine/s Measured Outcome
Gross 1994 RCT, Placebo (USA), 7388yrs., N= 80 Acetaminophen 0, q 6hrs 2days Influenza IIV3 Influenza HAI 40
Hsia 1994 RCT double-blind-placebo (USA), 65yrs; N=281 Acetylsalicylic acid day 1,2,3,5 and 7 Influenza IIV3 Serum specific antibody for 3 Influenza strains by ELISA-
Chernesky1993 RCT double-blind placebo (Canada), 65yrs; N = 185 Acetaminophen 0, 6hrs Influenza IIV3 Influenza HAI 40
Jackson 2015 RCT (USA)
50 years
N=1597
Acetylsalicylic acid H1N1 Influenza
Geometric mean HAI 21 days after receipt of the first study
308227-583794Study Characteristic
Study Characteristic
9842510306Results
Results
Quality assessment table to do!
2458873261176Assumption of homogeneity is not satisfied:
The timeframe for intervention with antipyretic is not concordant in all studies
The results of the RCT does not describe similar effects
The RCT includes studies of two different antipyretic (Acetaminophen) and (Acetylsalicylic acid)
00Assumption of homogeneity is not satisfied:
The timeframe for intervention with antipyretic is not concordant in all studies
The results of the RCT does not describe similar effects
The RCT includes studies of two different antipyretic (Acetaminophen) and (Acetylsalicylic acid)
180027343180Narrative synthesis
00Narrative synthesis
Not available, requesting to access the raw data of Hsia 1994
** Not available, requesting to access raw data od
1431730272855Pilot Quality Assessment Tool
Based on CASP Checklist for randomised controlled trial
&
00Pilot Quality Assessment Tool
Based on CASP Checklist for randomised controlled trial
&
Quality assessment table
*Will pilot this
Gross 1994
Hsia 1994
Chernesky 1993 Jackson 2015
Section A :
Study
Design for Randomised Controlled Trial Focused research Question Randomisation Dropout rate described and accepted Allocation Concealment Baseline comparability Score Key:
Yes = item adequately addressed
No = item not adequately addressed
/ = Item partially addressed
NS = Item not stated
NA = Not applicable
*We will also assess the study using Section B, C, D of the assessment tool
84406-295422Search Strategy
Search Strategy
Database Keywords Results
PubMed 2383
Ovid/Medline and Embase 629
Cochrane Trials 861
Study design
Methological quality
Results
Contribution
The reported significant difference in antibody response
Systematic reviews to look at content
The Effect of Prophylactic Antipyretic Administration on Post-Vaccination Adverse Reactions and Antibody Response in Children: A Systematic Review
Effect of a prophylaric administration of antipyretics on the immune response to pneumoccal conjugate vaccines in children: a systematic review
Systematic reviews to look at Formatting
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0106629&type=printablehttps://journals.sagepub.com/doi/full/10.1258/jrsm.2010.090441https://reader.elsevier.com/reader/sd/pii/S0302283818306833?token=30F50E4514904D78D9C223B30E2A233198DEEDF2D98615913D9EC015B598DD96510E2D4D387D36439CA0459B2AC535F1&originRegion=eu-west-1&originCreation=20221126222812Included studies:
Low-dose aspirin use does not diminish the immune response to monovalent H1N1 influenza vaccine in older adults.
Perfect for my introduction
However it is not been taking chronically
Immune response to influenza vaccination in the elderly is altered by chronic medication use
It is not measuring the primary outcome the same so it is not comparable
Augmentation of the immune response to influenza vaccine by acetylsalicylic acid: a clinical trial in a geriatric population the data in the clinical trial cannot be found
Effect of antipyretic analgesics on immune responses to vaccination - complete
Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial. Use to learn how to format the method
Impact on anti-rheumatic treatment on the immunogenicity of pandemic H1N1 influenzas vaccine in patients with arthritis they use NSAID
Vaccine immune response and side effects with the use of acetaminophen with influenza vaccine. Gross 1994
Immunogenicity and adverse reactions of influenza vaccination in elderly patients given acetaminophen or placebo. Chernsky 1993
Does ibuprofen present a problem for coronavirus disease or vaccination?
In 2020, a warning was issued in France that Ibuprofen exacerbates the symptoms of Covid-19 (Moore, N. et al. Drug Safety, 2020). This has triggered wide discussion regarding the validity of this association. One of the mechanistic suggestions has been that nonsteroidal anti-inflammatory drugs may depress the immune response. Such depression has provoked debate as to whether patients should avoid analgesics, such as Ibuprofen, prior to receiving Covid-19 vaccination (Terrie, Y.C. Pharmacy Times 87(9):30, 2021). Mechanistic and epidemiological studies are ongoing. This project will investigate a defined aspect of this issue, which triggers interest in the student. Investigation will be conducted by systematic review of the literature, using the guidelines of the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines (www.prismastatement.org). The student will begin by discussing the wide view of this field with the supervisor, identify their particular area of interest and compose a precise research question which can be addressed in the 10-week project period. This is a topical and exciting area in which to delve and develop further knowledge and insight. The systematic methodology gives opportunity to carry out the validity evaluation process to support medical decisions. The day-to-day conduct of the project will enable the student to apply their tenacity for robust research, attention to detail, and ability to critically assess evidence to conclude their investigation.
Ooi, E.E., et al. Review: Use of analgesics/antipyretics in the management of symptoms associated with Covid-19 vaccination. NPJ Vaccines 7:31 (2022) Use this website to find other searches using their references
http://doi.org/10.1038/s41541-022-00453-5 Saleh, E. et al. Effect of antipyretic analgesics on immune responses to vaccination.
Human Vaccines and Immunotherapeutics 12(9): 2391 (2016)
http://doi.org/10..1080/21645515.2016.1183077 Chen, J.S., et al.
Nonsteroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-COV-2 infection. Pathogenesis and Immunity 95(7): e00014-21 (2021)
http://doi.org/10.1128./JVI.00014-21
