Toxicity of New Investigation Pharmaceutical Compound ABX - Science Assignment Help

Assignment Task

Assignment
Your Company is testing the efficacy/toxicity of the new investigational pharmaceutical compound ABX. They administered ABX to a healthy volunteer (male, 31 year old, 80 kg) as a single intravenous injection of 5 mg/kg. The following plasma concentrations were collected:
Time (hours) Conc. (µg/mL)

• 0.1 1.142
• 0.5 1.0627
• 1 0.9712
• 8 0.2755
• 16 0.0653
• 24 0.0155
• 48 0.0002
• Calculate:
• Volume of distribution
• Elimination rate constant
• Elimination half-life
• Area under the curve
• Clearance

1-[The concentration at t=10 hours]

• The amount in the body at t=10 hours
• The fraction of the dose left in the body at t=24 hours
• How many half-lives it takes to eliminate 90% of the dose?
• What is the duration of action for compound ABX in this subject given that the minimum effective concentration is 0.25 µg/mL?

2-[Predict]:

• The plasma concentration at t=0 following a dose of 10 mg/kg
• The plasma concentration at t=14 hours for the 10mg/kg dose
• The fraction of the dose left in the body at t=24 hours
• The duration of the effect for the 10mg/kg dose
• Preliminary studies in monkeys indicated the onset of severe side effects when the plasma concentration exceeds 10 µg/mL. What is the maximum dose that can be administered in this subject?

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