Investigate the interaction between a particular protein and its  ligand to learn how the complex formed carries out a useful biological function.

The task 

For this assignment you are asked to investigate the interaction between a particular protein and its  ligand to learn how the complex formed carries out a useful biological function. You are expected to  delve into the interaction at the molecular level, ideally to describe exactly which amino acid  residue(s) of the protein are directly involved in forming the protein-ligand complex, i.e. to explain  how the interaction occurs. 

You are free to investigate a protein-ligand interaction of your own choosing and that you find  interesting. To help you, potential topics appear in the choice system on the LMS. You will research the scientific literature to gather information about the protein, its ligand and the  interaction between them, and then use this information to write a 1200-word report on the major  features of the protein-ligand complex and its biological function. 

This assessment task is to be completed individually and will contribute 40% to your overall mark for  this subject. Your written report will be assessed using the marking rubric provided.

Objectives 

The objectives of this task are: 

• To investigate a protein-ligand interaction at the molecular level in order to improve your understanding of the relationship between protein structure and biological function;
• To develop literature research skills: to select appropriate sources of reliable and relevant information from primary research articles and specialist texts in the scientific literature;
• To develop scientific writing skills: to use vocabulary appropriate for a general scientific audience; to write in full sentences with correct grammar and spelling; to develop a concise story that conveys the major features of the protein-ligand interaction in a logical sequence;
• To refine correct referencing and other acknowledgement skills: including in-text citations and a reference list using a standardized format; 

Choose a protein-ligand interaction

A comprehensive list of suitable protein-ligand interactions is provided in the Choice System on the LMS (See Figure1, green arrow). Consider which topic you would like to investigate and register a  topic. There is a limit on the number of students able to work on the same topic and it's a first-in first served system, so some topics may no longer be available when you attempt to register a particular topic. 

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